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Forskning på LLLT / Photobiomodulation

Uavhengig forskning har vist at lys med korrekt bølgelengde kan tilføre cellene nødvendig energi for å aktivere og raskt stimulere kroppens egen evne til å hele, samt øke sirkulasjonen. Fordelene med LED-lysterapi, også kalt LED-LLLT (Low Level Light Therapy, LLLT) eller photobiomodulation (PBM), er dokumentert i vitenskapelige studier og en rekke kliniske studier/case-studier, blant annet gjennom NASA og DARPA i USA.

Nedenfor finnes lenker og utdrag fra noen av studiene som er utført på området:

IS LIGHT-EMITTING DIODE PHOTOTHERAPY (LED-LLLT) REALLY EFFECTIVE?
"In conclusion, based on the published data and the authors’ own experience, LED phototherapy is proving to have more and more viable applications in many fields of medicine. However, it must always be remembered that not any old LED will do. In order to be effective, LED phototherapy must satisfy the following 3 criteria.

The LED system being used must have first of all, and most importantly, the correct wavelength for the target cells or chromophores. At present, the published literature strongly suggests 830 nm for all aspects of wound healing, pain, anti-inflammatory treatment and skin rejuvenation, with a combination of 415 nm and 633 nm for light-only treatment of active inflammatory acne vulgaris. If the wavelength is incorrect, optimum absorption will not occur and as the first law of photobiology states, the Grotthus-Draper law, without absorption there can be no reaction.

Secondly, the photon intensity, i.e., spectral irradiance or power density (W/cm²), must be adequate, or once again absorption of the photons will not be sufficient to achieve the desired result. If the intensity is too high, however, the photon energy will be transformed to excessive heat in the target tissue, and that is undesirable.

Finally, the dose or fluence must also be adequate (J/cm²), but if the power density is too low, then prolonging the irradiation time to achieve the ideal energy density or dose will most likely not give an adequate final result, because the Bunsen-Roscoe law of reciprocity, the 2nd law of photobiology, does not hold true for low incident power densities.

Provided these three criteria are met, LED phototherapy does indeed work, and has many useful aspects in clinical practice for practitioners in many surgical specialties. As an exciting extension of the monotherapy approach with LED-LLLT, and even more importantly, the combination of appropriate LED phototherapy as an adjunct to many other surgical or nonsurgical approaches where the architecture of the patient’s skin has been altered will almost certainly provide the clinician with even better results with less patient down-time, in a shorter healing period, and with excellent prophylaxis against obtrusive scar formation."

Les hele studien her:
IS LIGHT-EMITTING DIODE PHOTOTHERAPY (LED-LLLT) REALLY EFFECTIVE?

Det finnes betydelige bevis for at ulike bølgelengder av lys, inkludert R-NIR som leveres av LED, er avgjørende for å regulere mitokondrielle ATP-nivåer:

Mechanisms of ATP release in pain: role of pannexin and connexin channels

Mitochondrial cytochrome c oxidase is not the primary acceptor for near infrared light—it is mitochondrial bound water: the principles of low-level light therapy

Low-Level Light Therapy Potentiates NPe6-mediated Photodynamic Therapy in a Human Osteosarcoma Cell Line via Increased ATP

Nedenfor finnes kliniske studier utført med instrumenter fra Quantum Devices i USA, leverandøren av LED-teknologi til NASA.

Ved spørsmål, kontakt gjerne:
Marcus Odell
E-post: marcus.odell@modellight.se
Telefon: +46 70 455 48 22


Facial Rejuvenation

Effects of Low-Level Light Therapy on Hepatic Antioxidant Defense in Acute and Chronic Diabetic Rats

Near infrared light protects cardiomyocytes from hypoxia and reoxygenation injury by a nitric oxide dependent mechanism

Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity

Modulation of rat pituitary growth hormone by 670 nm light

NEAR-INFRARED LIGHT VIA LIGHT-EMITTING DIODE TREATMENT IS THERAPEUTIC AGAINST ROTENONE- AND 1-METHYL-4- PHENYLPYRIDINIUM ION-INDUCED NEUROTOXICITY

Photobiomodulation for the Treatment of Retinal Injury and Retinal Degenerative Diseases

PHOTOMODULATION OF CYTOCHROME OXIDASE

Embryonic Growth and Hatching Implications of Developmental 670-nm Phototherapy and Dioxin Co-exposure

Stressed Cells Survive Better with Light

Nature Inspired Hay Fever Therapy

From Microtornadoes to Facial Rejuvenation: Implication of Interfacial Water Layers

Effects of Continuous-Wave (670-nm) Red Light on Wound Healing

Biostimulatory Windows in Low-Intensity Laser Activation: Lasers, Scanners, and NASA’s Light-Emitting Diode Array System

Clinical and Experimental Applications of NIR-LED Photobiomodulation

DARPA Soldier Self Care: Rapid Healing of Laser Eye Injuries with Light Emitting Diode Technology

Effect of NASA Light-Emitting Diode Irradiation on Molecular Changes for Wound Healing in Diabetic Mice

Effects of 670-nm Phototherapy on Development

Evaluation of photodynamic therapy near functional brain tissue in patients with recurrent brain tumors

Innate immunity for biodefense: A strategy whose time has come

Light emitting diode treatment reverses the effect of TTX on cytochrome oxidase in neurons

Light Emitting Diodes as a Light Source for Intraoperative Photodynamic Therapy

Medical Applications of Space Light-Emitting Diode Technology - Space Station and Beyond

Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy

NASA Light Emitting Diode Medical Applications From Deep Space to Deep Sea

The NASA Light-Emitting Diode Medical Program - Progress in Space Flight and Terrestrial Applications

NASA Light-Emitting Diodes for the Prevention of Oral Mucositis in Pediatric Bone Marrow Transplant Patients

Photobiomodulation Directly Benefits Primary Neurons Functionally Inactivated by Toxins

PHOTOBIOMODULATION PARTIALLY RESCUES VISUAL CORTICAL NEURONS FROM CYANIDE-INDUCED APOPTOSIS

A Preliminary Investigation into Light-Modulated Replication of Nanobacteria and Heart Disease

Therapeutic photobiomodulation for methanol-induced retinal toxicity